PPVD2024

The European Conference on Neonatal and Paediatric Pulmonary Vascular disease invites you to join the 6th edition of the conference. After 5 successful past editions, the latest developments in field of pulmonary vascular disease will be presented 9, 10 & 11 October 2024

Pre-conference symposium, fully dedicated to the TBX4-syndrome
We invite you to the first in-person TBX4-syndrome symposium, co-organized with TBX4Life. TBX4Life is an international consortium uniting clinicians, scientists, patients and families in the quest for a cure of the TBX4 syndrome, a multifaceted disease affecting infants, children and adults, emerging as one of the most prevalent causes of heritable pulmonary hypertension. This symposium brings together scientists, neonatologists, pediatricians, cardiologists, pulmonologists, intensivists, nurses and other interested actors, with the goal of raising awareness, sharing knowledge, advancing research and shaping the future of care for the TBX4 syndrome. You are warmly invited to participate and submit cases to be discussed during the round table session.

Program

TBX4Life pre-conference symposium

The TBX4-syndrome, clinical features and exploring the path to a cure

co-organized by TBX4Life

12.00 - 12.45

Doors open and registration

12.45 – 13.00

Welcome and Introduction

13:00 – 13.30

Steve Abman (USA)

Keynote lecture: Pediatric Pulmonary Vascular Diseases spectrum and the place of TBX4

13.30 – 14.00

Mieke Kerstjens-Frederikse (NL)

Clinical lecture: Clinical and genetic aspects of TBX4 syndrome across the lifespan

14.00 – 14.30

Anne-Karina Perl (USA)

Translational lecture: Animal and human cell-based models: path to a cure for TBX4 syndrome

14.30 – 16.00

Cara Morgan (UK)

Mary Mullen (USA)
Maria J del Cerro (SP)
Rebeca Weldeghebreal (NL)

Expert panel members:
Shahin Moledina (UK)
Rolf Berger (NL)

Round table: Management of difficult TBX4 cases: case presentation and expert panel discussion

16.00 – 16.30

Break

16.30 – 17.00

Aurore Coulomb-L’Hermine (FR)

Clinical lecture: Pathology of developmental lung disorders

17.00 – 18.30

Martina Prapa (UK)

Olivier Danhaive (BE)

TBX4Life clinical working group workshop

18.30

Closing remarks

08.00 – 09.00

Registration, with coffee and croissants

09.00 – 09.10

Welcome and Opening

Rolf Berger

09.10 – 09.40

Pediatric PH beyond Niche: Exploring the True Scope of PH in Childhood

Mary Mullen

09.40 – 10.05

Clinical relevance of Genetic variations in neonatal and pediatric PH

Maria del Cerro

10.05 – 10.30

New insights in molecular mechanisms and new treatment targets

Soni Pullamsetti

10.30 – 11.00

Coffee break

What’s new from the WSPH 2024 pediatric task force (11.00-12.40 hrs)

11.00 – 11.25

Current definition and classification of pediatric PH useful in clinical practice?

Dunbar Ivy

11.25 – 11.50

Advancements in pharmacological treatment, a new treatment algorithm

Alessandra Manes

11.50 – 12.15

Current approach to surgical interventions, when and how?

Usha Krishnan

12.15 – 12.40

Referral for evaluation or listing for lung transplantation

Mary Mullen

12.40 – 14.00

Lunch

New insights in the world of neonatal PH (14.00-15.40 hrs)

14.00 – 14.25

A diagnosis of PH in the neonate and the role of “targeted echocardiography”

María Carmen Bravo

14.25 – 14.50

Diagnostic algorithm in “therapy-refractory” neonatal PH

Olivier Danhaive

14.50 – 15.15

Neonatal PH more than pulmonary arterial pressure: congenital diaphragmatic hernia, pulmonary vein stenosis and genetics

Usha Krishnan

15.15 - 15.40

A role for PAH targeted treatment in PH associated with BPD and other developmental lung diseases?

Jeff Fineman

15.40 - 16.10

Tea Break

New approaches to risk stratification in paediatric PH (16.10-17.25 hrs)

16.10 - 16.35

Prognosticators and Risk stratification in paediatric PH

Menno Douwes

16.35 - 17.00

Integration of genetics and -omics in risk stratification

Allen Everett

17.00 - 17.25

Should we use AI in prediction models in paediatric PH?

Chantal Lokhorst

18.30

Conference dinner at Prinsenhof Groningen

Martinikerkhof 23 Groningen

07.30 - 08.30

Registration

Old and new methods for monitoring paediatric PH (08.30-10.30 hrs)

08.30 - 08.55

The use of MRI in diagnosis and follow up

Shahin Moledina

08.55 - 09.20

Serial invasive hemodynamics for monitoring children with PAH

Julien Grynblat

09.20 - 09.45

Quantitative analysis of the pulmonary vasculature using CT-scan

Rosaria Ferreira

09.45 - 10.10

Unveiling pulmonary vascular remodeling: Synchrotron-based 3D-imaging

Karin Tran Lundmark

10.10 - 10.30

Accelerometry as treatment target and clinical relevant end-point?

Marc Jan Ploegstra

10.30 – 11.00

Coffee break

Challenging cases to challenge the experts (11.00-12.15 hrs)

11.00 - 11.25

Paediatric Pulmonary Arterial Hypertension: a clinical report with an unusual course

Sofia Rito

11.25 - 11.50

Complex Persistent Pulmonary Hypertension of the Newborn associated with Sertraline exposure

Joseph Pattathu

11.50 - 12.15

Pediatric Portopulmonary Hypertension: Unveiling Challenges in Diagnosis and Treatment

Manuela Lopes

12.15 - 13.30

Lunch

The elusive right heart in paediatric pulmonary hypertension (13.30-14.45 hrs)

13.30 - 13.55

Clinical assessment of RV performance and its interaction with the pulmonary vasculature

Mark Friedberg

13.55 - 14.20

The role of the right atrium in clinical assessment of PH in children and neonates

Paul Critser

14.20 - 14.45

Computational Modeling of the RV and pulmonary circulation: potential clinical applications in pediatric PH

Christobal Bertoglio

14.45 - 15.15

Tea Break

Work in progress in Paediatric and Neonatal Pulmonary Vascular Disease

15.15 - 15.40

How to move forward in Clinical trials in infants and children with PH

Steve Abman

15.40 - 16.10

RepPHyNe registry, the need for real world data on neonatal pulmonary hypertension

Cara Morgan

16.10 - 16.35

Will future PAH drugs ever be approved for neonates and children? Regulators, trials and registries

Maurice Beghetti

16.35 - 16.45

Discussion

Panel

16.45 - 17.00

Closure

Annabelle Barnes

Research participation: viewpoints from young people with pulmonary hypertension

Dafni Charisopoulou

Clinical Characteristics and Outcomes in a Contemporary Pediatric Eisenmenger’s Syndrome Population

Natalia Gallego-Zazo

Pulmonary arterial hypertension associated with variants in the TBX4 gene

Manolis Mavrogiannis

Inflammasomme in experimental pulmonary arterial hypertension, a natural history study

Emma Olson-Jackson

Outcomes of Transcatheter ASD Closure in Infants Less Than 6 kg with Developmental Lung Disease

Rebeca Weldeghebreal

High nlrp3 inflammasome expression in lungs from pediatric pulmonary arterial hypertension patients

Yannick Yung

Galectin-3 as a Prognostic Biomarker in Children with Pulmonary Hypertension

Faculty

Steven Abman

Department of Pediatrics University of Colorado, Pediatric Heart Lung Center, Children's Hospital Colorado, Aurora, Colorado, USA

Maurice Beghetti

Pediatric Cardiology Unit, Department of Women, Child and Adolescent Medicine, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland

Rolf M.F. Berger

Center for Congenital Heart Diseases, Pediatric Cardiology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, the Netherlands

Christobal Bertoglio

Bernoulli Institute, University of Groningen, The Netherlands

Aurore Coulomb-L’Hermine

Hôpital Armand-Trousseau (Hôpitaux Universitaires Est Parisien) Service d'Anatomie et Cytologie Pathologiques, France

Paul Critser

Department of Pediatrics Cincinnati Children's Hospital Medical Center, College of Medicine, University of Cincinnati, Cincinnati, OH, USA

Olivier Danhaive

Division of Neonatology, Saint-Luc University Hospital, UCLouvain, Brussels, Belgium

Maria J. Del Cerro

Pediatric Cardiology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), University of Alcalá, Madrid, Spain

Menno Douwes

Center for Congenital Heart Diseases, Pediatric Cardiology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, the Netherlands

Allen Everett

Blalock-Taussig-Thomas Congenital Heart Center, Department of Pediatrics, Johns Hopkins University, Baltimore, MD

Rosaria Ferreira

Center for Congenital Heart Diseases, Pediatric Cardiology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, the Netherlands

Jeff Fineman

Division of Critical Care, Department of Pediatrics University of California, San Francisco San Francisco California USA

Mark Friedberg

Department of Cardiology, The Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada

Julien Grynblat

M3C-Necker, Hôpital Necker-Enfants malades, Université de Paris Cité, Cardiologie Congénitale et Pédiatrique; Université Paris-Saclay, Faculty of Medicine Le Kremlin-Bicêtre and INSERM UMR_S 999, Hôpital Marie Lannelongue Le Plessis Robinson Paris France

Dunbar Ivy

Department of Pediatrics University of Colorado, Pediatric Heart Lung Center, Division of Pediatric Cardiology Children's Hospital Colorado, Aurora, Colorado, USA

Wilhelmina Kerstjens-Frederikse

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands

Usha Krishnan

Department of Pediatrics, Division of Pediatric Cardiology, Columbia University Irving Medical Center, Morgan Stanley Childrens Hospital of New York Presbyterian Hospital, New York, USA

Chantal Lokhorst

Center for Congenital Heart Diseases, Pediatric Cardiology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, the Netherlands

Manuela Lopes

Paediatric Hospital-ULS Coimbra, Portugal

Alessandra Manes

Cardiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

Shahin Moledina

National Paediatric Pulmonary Hypertension Service UK, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

Cara Morgan

Neonatal Research Fellow, Liverpool Women’s NHS Foundation Trust and Honorary Clinical Fellow in Women and Children’s Health, University of Liverpool and Paediatric Cardiology Trainee, Great Ormond Street Hospital for Children NHS Foundation, London, UK

Mary Mullen

Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA

Joseph Pattathu

LMU Klinikum, Munich, Germany

Anne-Karina Perl

Department of Pediatrics, and the Perinatal Institute and Section of Neonatology, Perinatal and Pulmonary Biology and Molecular and Developmental Biology Graduate Program, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

Mark-Jan Ploegstra

Center for Congenital Heart Diseases, Pediatric Cardiology, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, the Netherlands

Matina Prapa

Department of Clinical Genetics, St George's University Hospitals NHS Foundation Trust, London, UK

Soni Pullamsetti

Institute for Lung Health (ILH), Justus-Liebig-University Giessen, Giessen, Germany and Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

Sofia Rito

Paediatric Hospital - ULS Coimbra, Portugal

Karin Tran-Lundmark

The Pediatric Heart Center, Skåne University Hospital, Department of Experimental Medical Science, Faculty of Medicine and Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden

Rebeca Weldeghebreal

University Medical Center Groningen, Pediatrics, the Netherlands

PPVD2024

Program

Faculty

Steven Abman

Maurice Beghetti

Rolf M.F. Berger

Christobal Bertoglio

Aurore Coulomb-L’Hermine

Paul Critser

Olivier Danhaive

Maria J. Del Cerro

Menno Douwes

Allen Everett

Rosaria Ferreira

Jeff Fineman

Mark Friedberg

Julien Grynblat

Dunbar Ivy

Wilhelmina Kerstjens-Frederikse

Usha Krishnan

Chantal Lokhorst

Manuela Lopes

Alessandra Manes

Shahin Moledina

Cara Morgan

Mary Mullen

Joseph Pattathu

Anne-Karina Perl

Mark-Jan Ploegstra

Matina Prapa

Soni Pullamsetti

Sofia Rito

Karin Tran-Lundmark

Rebeca Weldeghebreal

Sponsors

Gold Sponsors

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